| Player | Team | Opponent | Venue | Attempts | Yards | TDs | 1st Downs | Fumbles | Fumbles Lost |
|---|---|---|---|---|---|---|---|---|---|
| James Cook | BUF | NYJ | Home | 22.3 | 129.2 | 1.7 | 5.6 | 1.1 | 1.0 |
| Jonathan Taylor | IND | HOU | Away | 21.5 | 123.4 | 2.7 | 5.5 | 0.2 | 0.2 |
| Bijan Robinson | ATL | NO | Home | 20.9 | 118.0 | 0.6 | 5.2 | 0.9 | 0.8 |
| Derrick Henry | BAL | PIT | Away | 20.1 | 115.1 | 1.7 | 6.0 | 0.9 | 0.9 |
| Jahmyr Gibbs | DET | CHI | Away | 16.7 | 111.0 | 1.8 | 4.6 | 0.7 | 0.7 |
| Javonte Williams | DAL | NYG | Away | 16.6 | 92.8 | 1.3 | 4.9 | 0.2 | 0.3 |
| De'Von Achane | MIA | NE | Away | 16.7 | 90.6 | 0.7 | 4.2 | 0.2 | 0.1 |
| Saquon Barkley | PHI | WAS | Home | 19.8 | 89.3 | 1.0 | 4.3 | 0.0 | 0.0 |
| Breece Hall | NYJ | BUF | Away | 15.9 | 87.3 | 0.7 | 4.6 | 0.3 | 0.6 |
| Kyren Williams | LA | ARI | Home | 17.3 | 85.3 | 1.4 | 5.9 | 0.6 | 0.7 |
| D'Andre Swift | CHI | DET | Home | 17.2 | 79.9 | 1.3 | 4.8 | 0.5 | 0.7 |
| Travis Etienne | JAX | TEN | Home | 17.1 | 77.6 | 1.2 | 4.2 | 0.0 | 0.0 |
| Quinshon Judkins | CLE | CIN | Away | 17.9 | 73.8 | 0.8 | 4.7 | 0.0 | 0.0 |
| Josh Jacobs | GB | MIN | Away | 18.4 | 73.1 | 1.4 | 4.9 | 0.9 | 0.7 |
| Christian McCaffrey | SF | SEA | Home | 21.1 | 71.5 | 0.9 | 4.7 | 0.2 | 0.0 |
| Rico Dowdle | CAR | TB | Away | 15.4 | 70.4 | 0.6 | 3.8 | 0.0 | 0.1 |
| David Montgomery | DET | CHI | Away | 12.1 | 69.4 | 1.5 | 3.7 | 0.6 | 0.6 |
| TreVeyon Henderson | NE | MIA | Home | 13.2 | 66.9 | 0.9 | 3.5 | 0.3 | 0.5 |
| Omarion Hampton | LAC | DEN | Away | 16.0 | 66.6 | 0.8 | 4.2 | 0.0 | 0.0 |
| Chase Brown | CIN | CLE | Home | 15.8 | 65.5 | 0.8 | 3.8 | 0.4 | 0.1 |
| Ashton Jeanty | LV | KC | Home | 17.6 | 64.6 | 0.6 | 3.6 | 0.3 | 0.4 |
| Kenneth Walker III | SEA | SF | Away | 14.3 | 63.9 | 0.5 | 3.7 | 0.0 | 0.0 |
| Kimani Vidal | LAC | DEN | Away | 16.0 | 63.0 | 0.4 | 3.7 | 0.3 | 0.0 |
| Malik Willis | GB | MIN | Away | 12.5 | 62.5 | 1.6 | 5.5 | 1.7 | 1.6 |
| Bucky Irving | TB | CAR | Home | 16.9 | 62.1 | 0.3 | 3.4 | 0.4 | 0.5 |
| Jacory Croskey-Merritt | WAS | PHI | Away | 13.0 | 61.1 | 1.3 | 4.0 | 0.6 | 0.6 |
| Jordan Mason | MIN | GB | Home | 13.8 | 59.9 | 0.9 | 4.3 | 0.6 | 0.5 |
| Kyle Monangai | CHI | DET | Home | 13.9 | 58.5 | 0.8 | 3.4 | 0.0 | 0.1 |
| Jaylen Warren | PIT | BAL | Home | 14.4 | 57.9 | 0.8 | 3.9 | 0.4 | 0.1 |
| Tony Pollard | TEN | JAX | Away | 14.7 | 57.3 | 0.4 | 3.6 | 0.6 | 0.6 |
| Aaron Jones | MIN | GB | Home | 14.5 | 56.9 | 0.2 | 3.1 | 0.5 | 0.2 |
| Chris Rodriguez Jr. | WAS | PHI | Away | 12.3 | 54.4 | 1.2 | 4.3 | 0.1 | 0.1 |
| Blake Corum | LA | ARI | Home | 11.2 | 54.3 | 1.0 | 3.7 | 0.1 | 0.2 |
| Alvin Kamara | NO | ATL | Away | 14.0 | 54.0 | 0.1 | 3.0 | 0.4 | 0.4 |
| Emari Demercado | ARI | LA | Away | 7.8 | 53.3 | 0.0 | 2.3 | 0.4 | 0.6 |
| Tank Bigsby | PHI | WAS | Home | 8.8 | 52.6 | 0.3 | 2.8 | 0.1 | 0.0 |
| Tyrone Tracy Jr. | NYG | DAL | Home | 13.1 | 51.3 | 0.5 | 3.7 | 0.1 | 0.1 |
| Jaxson Dart | NYG | DAL | Home | 9.3 | 50.7 | 1.9 | 5.3 | 0.9 | 0.5 |
| Tyler Huntley | BAL | PIT | Away | 7.3 | 49.1 | 0.0 | 4.0 | 0.2 | 0.3 |
| Zach Charbonnet | SEA | SF | Away | 12.9 | 48.8 | 1.2 | 4.0 | 0.0 | 0.0 |
| Josh Allen | BUF | NYJ | Home | 8.9 | 48.2 | 2.0 | 4.3 | 1.1 | 0.7 |
| Jaylen Wright | MIA | NE | Away | 11.5 | 47.8 | 0.4 | 3.2 | 0.0 | 0.1 |
| Malik Davis | DAL | NYG | Away | 9.0 | 47.6 | 0.5 | 1.9 | 0.0 | 0.0 |
| Woody Marks | HOU | IND | Home | 14.7 | 47.6 | 0.3 | 3.4 | 0.3 | 0.1 |
| RJ Harvey | DEN | LAC | Home | 12.6 | 46.9 | 1.2 | 2.9 | 0.3 | 0.4 |
| Ronnie Rivers | LA | ARI | Home | 9.7 | 45.9 | 0.0 | 2.5 | 0.1 | 0.2 |
| Rachaad White | TB | CAR | Home | 11.6 | 45.8 | 0.8 | 3.7 | 0.0 | 0.0 |
| Tyler Allgeier | ATL | NO | Home | 12.9 | 45.5 | 1.1 | 3.6 | 0.2 | 0.2 |
| Emanuel Wilson | GB | MIN | Away | 11.4 | 45.0 | 0.3 | 3.1 | 0.2 | 0.2 |
| Keaton Mitchell | BAL | PIT | Away | 7.8 | 45.0 | 0.0 | 2.0 | 0.7 | 0.3 |
| Audric Estimé | NO | ATL | Away | 8.4 | 43.8 | 0.3 | 3.5 | 0.0 | 0.0 |
| Justin Herbert | LAC | DEN | Away | 8.4 | 43.4 | 0.3 | 3.6 | 0.9 | 0.3 |
| Kene Nwangwu | NYJ | BUF | Away | 7.5 | 42.8 | 0.1 | 2.7 | 0.0 | 0.1 |
| Lamar Jackson | BAL | PIT | Away | 8.4 | 42.7 | 0.2 | 3.1 | 0.3 | 0.3 |
| Devin Neal | NO | ATL | Away | 11.6 | 42.6 | 0.4 | 2.9 | 0.0 | 0.0 |
| Rhamondre Stevenson | NE | MIA | Home | 11.7 | 42.4 | 0.7 | 2.3 | 0.6 | 0.9 |
| Malachi Corley | CLE | CIN | Away | 3.6 | 42.2 | 0.0 | 2.9 | 0.0 | 0.0 |
| Nick Chubb | HOU | IND | Home | 11.5 | 41.7 | 0.5 | 2.4 | 0.1 | 0.1 |
| Kareem Hunt | KC | LV | Away | 12.0 | 41.0 | 1.0 | 4.2 | 0.4 | 0.3 |
| Shedeur Sanders | CLE | CIN | Away | 4.3 | 40.4 | 0.4 | 1.8 | 0.0 | 0.0 |
| Isiah Pacheco | KC | LV | Away | 11.3 | 39.5 | 0.2 | 3.0 | 0.0 | 0.0 |
| Chuba Hubbard | CAR | TB | Away | 11.1 | 38.9 | 0.1 | 3.0 | 0.3 | 0.4 |
| Sean Tucker | TB | CAR | Home | 10.2 | 37.7 | 1.4 | 2.9 | 0.4 | 0.0 |
| Ray Davis | BUF | NYJ | Home | 9.6 | 37.7 | 0.0 | 2.1 | 0.2 | 0.2 |
| Jeremy McNichols | WAS | PHI | Away | 7.2 | 37.5 | 0.3 | 2.6 | 0.7 | 0.8 |
| Michael Carter | ARI | LA | Away | 10.2 | 36.1 | 0.0 | 2.6 | 0.0 | 0.0 |
| Samaje Perine | CIN | CLE | Home | 9.3 | 35.5 | 0.6 | 3.3 | 1.1 | 1.0 |
| Jalen Hurts | PHI | WAS | Home | 8.7 | 34.7 | 1.1 | 3.8 | 0.9 | 0.6 |
| Devin Singletary | NYG | DAL | Home | 9.7 | 34.2 | 0.9 | 2.5 | 0.1 | 0.1 |
| Jaleel McLaughlin | DEN | LAC | Home | 7.2 | 34.0 | 0.5 | 1.6 | 0.0 | 0.1 |
| Isaiah Davis | NYJ | BUF | Away | 5.7 | 33.9 | 0.4 | 1.0 | 0.0 | 0.1 |
| Kenneth Gainwell | PIT | BAL | Home | 8.7 | 33.6 | 0.5 | 2.7 | 0.5 | 0.2 |
| Baker Mayfield | TB | CAR | Home | 4.9 | 33.2 | 0.3 | 3.1 | 0.3 | 0.0 |
| Raheim Sanders | CLE | CIN | Away | 9.6 | 31.7 | 0.4 | 2.7 | 0.0 | 0.0 |
| Ty Chandler | MIN | GB | Home | 9.6 | 30.3 | 0.0 | 1.3 | 0.1 | 0.1 |
| J.J. McCarthy | MIN | GB | Home | 7.8 | 30.2 | 0.8 | 2.6 | 1.1 | 0.1 |
| Drake Maye | NE | MIA | Home | 7.6 | 29.1 | 0.5 | 3.0 | 0.5 | 0.2 |
| Trevor Lawrence | JAX | TEN | Home | 7.1 | 27.7 | 1.5 | 3.8 | 0.3 | 0.4 |
| Tyler Shough | NO | ATL | Away | 7.5 | 27.5 | 0.3 | 2.3 | 0.4 | 0.6 |
| Brian Robinson | SF | SEA | Home | 8.3 | 27.3 | 0.2 | 1.4 | 0.0 | 0.1 |
| Bhayshul Tuten | JAX | TEN | Home | 8.4 | 26.6 | 0.9 | 2.4 | 0.0 | 0.1 |
| Caleb Williams | CHI | DET | Home | 5.8 | 26.2 | 0.5 | 2.5 | 1.0 | 0.1 |
| Brock Purdy | SF | SEA | Home | 7.2 | 25.2 | 0.7 | 3.0 | 0.0 | 0.1 |
| Bo Nix | DEN | LAC | Home | 6.6 | 25.0 | 1.0 | 2.4 | 0.5 | 0.4 |
| Ollie Gordon II | MIA | NE | Away | 8.0 | 24.7 | 0.5 | 2.7 | 0.0 | 0.1 |
| Bryce Young | CAR | TB | Away | 6.1 | 24.7 | 0.1 | 1.8 | 0.4 | 0.6 |
| Dylan Sampson | CLE | CIN | Away | 7.7 | 24.7 | 0.0 | 1.4 | 0.0 | 0.0 |
| Tyjae Spears | TEN | JAX | Away | 7.4 | 23.7 | 0.2 | 2.1 | 0.0 | 0.1 |
| Jordan Love | GB | MIN | Away | 5.2 | 23.4 | 0.0 | 2.0 | 0.9 | 0.2 |
| Dak Prescott | DAL | NYG | Away | 5.5 | 22.7 | 0.2 | 2.1 | 0.6 | 0.0 |
| Jacoby Brissett | ARI | LA | Away | 5.0 | 21.8 | 0.1 | 2.6 | 0.3 | 0.0 |
| Zavier Scott | MIN | GB | Home | 6.0 | 21.3 | 0.0 | 1.3 | 1.1 | 1.0 |
| Tyler Badie | DEN | LAC | Home | 4.8 | 18.5 | 0.0 | 1.3 | 0.0 | 0.1 |
| Ameer Abdullah | IND | HOU | Away | 4.2 | 17.9 | 0.1 | 0.0 | 0.0 | 0.0 |
| C.J. Stroud | HOU | IND | Home | 5.7 | 17.0 | 0.1 | 2.7 | 0.9 | 0.0 |
| Cam Ward | TEN | JAX | Away | 4.9 | 16.2 | 0.1 | 2.3 | 0.0 | 0.1 |
| Hassan Haskins | LAC | DEN | Away | 6.5 | 16.0 | 0.0 | 1.3 | 0.0 | 0.0 |
| Evan Hull | NO | ATL | Away | 6.2 | 15.3 | 0.0 | 2.1 | 0.0 | 0.0 |
| Ty Johnson | BUF | NYJ | Home | 4.2 | 14.9 | 0.5 | 0.8 | 0.2 | 0.2 |
| Trayveon Williams | CLE | CIN | Away | 3.6 | 14.7 | 0.0 | 0.7 | 0.0 | 0.0 |
| Tahj Brooks | CIN | CLE | Home | 4.5 | 11.2 | 0.0 | 0.2 | 0.2 | 0.2 |
| Tyler Goodson | IND | HOU | Away | 2.9 | 11.1 | 0.2 | 0.1 | 0.0 | 0.0 |
| Sam Darnold | SEA | SF | Away | 3.9 | 7.0 | 0.0 | 1.4 | 0.8 | 0.5 |
| Jared Goff | DET | CHI | Away | 4.1 | 6.9 | 0.0 | 3.4 | 2.0 | 1.4 |
| Quinn Ewers | MIA | NE | Away | 4.9 | 5.7 | 0.0 | 2.6 | 1.4 | 0.1 |
| D'Ernest Johnson | NE | MIA | Home | 3.8 | 5.6 | 0.0 | 0.0 | 0.0 | 0.2 |
| Mac Jones | SF | SEA | Home | 4.7 | 4.7 | 0.0 | 1.3 | 0.5 | 0.0 |
| Joe Burrow | CIN | CLE | Home | 3.0 | 4.5 | 0.0 | 1.6 | 0.2 | 0.2 |
| Joe Flacco | CIN | CLE | Home | 4.5 | 0.6 | 0.0 | 0.9 | 0.2 | 0.2 |
| Kirk Cousins | ATL | NO | Home | 5.7 | 0.0 | 1.6 | 4.0 | 0.9 | 0.0 |