| Player | Team | Opponent | Venue | Attempts | Yards | TDs | 1st Downs | Fumbles | Fumbles Lost |
|---|---|---|---|---|---|---|---|---|---|
| Jonathan Taylor | IND | TEN | Home | 21.5 | 151.3 | 2.8 | 7.1 | 0.0 | 0.1 |
| Bijan Robinson | ATL | MIA | Home | 19.0 | 148.8 | 1.3 | 6.6 | 0.6 | 0.1 |
| Derrick Henry | BAL | CHI | Home | 18.9 | 128.6 | 1.3 | 6.0 | 1.1 | 1.3 |
| Rico Dowdle | CAR | BUF | Home | 17.8 | 115.2 | 0.9 | 5.6 | 0.4 | 0.6 |
| Javonte Williams | DAL | DEN | Away | 16.7 | 100.0 | 1.2 | 4.6 | 0.4 | 0.5 |
| James Cook | BUF | CAR | Away | 16.4 | 90.8 | 1.1 | 4.8 | 0.4 | 0.1 |
| J.K. Dobbins | DEN | DAL | Home | 17.9 | 89.9 | 1.1 | 5.1 | 0.0 | 0.0 |
| Bucky Irving | TB | NO | Away | 19.2 | 83.9 | 0.3 | 4.1 | 0.8 | 0.7 |
| De'Von Achane | MIA | ATL | Away | 13.6 | 77.1 | 0.9 | 4.0 | 0.4 | 0.0 |
| Saquon Barkley | PHI | NYG | Home | 20.3 | 74.9 | 0.9 | 3.9 | 0.0 | 0.0 |
| Christian McCaffrey | SF | HOU | Away | 20.3 | 73.9 | 1.1 | 5.1 | 0.1 | 0.1 |
| Cam Skattebo | NYG | PHI | Away | 17.4 | 73.8 | 1.4 | 5.2 | 0.7 | 0.7 |
| Josh Jacobs | GB | PIT | Away | 18.0 | 72.1 | 1.6 | 5.0 | 1.0 | 0.7 |
| Breece Hall | NYJ | CIN | Away | 14.9 | 71.1 | 0.0 | 4.5 | 0.3 | 0.4 |
| Jordan Mason | MIN | LAC | Away | 15.0 | 67.7 | 1.3 | 4.9 | 1.1 | 0.7 |
| D'Andre Swift | CHI | BAL | Away | 15.5 | 60.6 | 1.1 | 4.2 | 0.4 | 0.4 |
| Quinshon Judkins | CLE | NE | Away | 18.8 | 60.4 | 0.9 | 4.8 | 0.0 | 0.0 |
| Jacory Croskey-Merritt | WAS | KC | Away | 11.4 | 59.9 | 1.1 | 3.9 | 0.7 | 0.9 |
| Jeremy McNichols | WAS | KC | Away | 5.2 | 59.8 | 1.0 | 3.5 | 0.0 | 0.1 |
| Jayden Daniels | WAS | KC | Away | 10.4 | 59.8 | 0.3 | 3.9 | 0.4 | 0.6 |
| Chuba Hubbard | CAR | BUF | Home | 15.2 | 59.8 | 0.1 | 4.7 | 0.1 | 0.2 |
| Dameon Pierce | HOU | SF | Home | 10.4 | 57.8 | 0.6 | 1.7 | 0.7 | 0.0 |
| Marcus Mariota | WAS | KC | Away | 6.7 | 56.7 | 1.3 | 3.5 | 1.0 | 1.2 |
| Alvin Kamara | NO | TB | Home | 16.8 | 56.3 | 0.4 | 2.6 | 0.0 | 0.0 |
| Nate Carter | ATL | MIA | Home | 7.7 | 55.6 | 0.0 | 2.2 | 0.8 | 0.9 |
| Chase Brown | CIN | NYJ | Home | 15.7 | 54.7 | 0.3 | 2.3 | 0.4 | 0.0 |
| Kimani Vidal | LAC | MIN | Home | 11.6 | 53.9 | 0.1 | 2.3 | 0.2 | 0.2 |
| Jaxson Dart | NYG | PHI | Away | 10.3 | 52.9 | 1.3 | 5.1 | 1.0 | 0.2 |
| Justin Fields | NYJ | CIN | Away | 8.5 | 51.0 | 0.9 | 3.6 | 0.4 | 0.6 |
| Jaylen Warren | PIT | GB | Home | 14.3 | 50.2 | 0.0 | 3.4 | 0.0 | 0.0 |
| Nick Chubb | HOU | SF | Home | 12.6 | 48.5 | 0.8 | 2.2 | 0.1 | 0.0 |
| Tony Pollard | TEN | IND | Away | 15.4 | 47.4 | 0.4 | 3.2 | 0.7 | 0.9 |
| Rachaad White | TB | NO | Away | 11.5 | 47.1 | 1.0 | 4.1 | 0.2 | 0.1 |
| Baker Mayfield | TB | NO | Away | 6.9 | 47.0 | 0.0 | 3.5 | 0.7 | 0.1 |
| Tyler Allgeier | ATL | MIA | Home | 11.0 | 46.8 | 0.9 | 3.8 | 0.0 | 0.1 |
| Justin Herbert | LAC | MIN | Home | 8.1 | 44.1 | 0.1 | 4.2 | 1.0 | 0.7 |
| Cam Akers | MIN | LAC | Away | 6.6 | 42.7 | 0.1 | 1.9 | 0.1 | 0.2 |
| Tyrone Tracy Jr. | NYG | PHI | Away | 11.4 | 42.1 | 0.4 | 2.9 | 0.2 | 0.2 |
| DJ Giddens | IND | TEN | Home | 10.4 | 41.3 | 0.2 | 2.1 | 0.0 | 0.0 |
| Patrick Mahomes | KC | WAS | Home | 7.6 | 41.1 | 1.1 | 3.4 | 0.1 | 0.0 |
| Josh Allen | BUF | CAR | Away | 7.5 | 40.9 | 0.9 | 3.2 | 1.1 | 0.6 |
| Isiah Pacheco | KC | WAS | Home | 10.7 | 40.2 | 0.3 | 2.6 | 0.1 | 0.0 |
| Justice Hill | BAL | CHI | Home | 5.0 | 39.6 | 0.7 | 1.9 | 0.2 | 0.4 |
| Emanuel Wilson | GB | PIT | Away | 8.5 | 38.9 | 0.7 | 2.7 | 0.2 | 0.3 |
| Jalen Hurts | PHI | NYG | Home | 10.6 | 38.0 | 1.3 | 4.9 | 0.4 | 0.0 |
| Ray Davis | BUF | CAR | Away | 10.5 | 38.0 | 0.0 | 1.9 | 0.0 | 0.0 |
| Tyjae Spears | TEN | IND | Away | 9.0 | 37.0 | 0.0 | 2.8 | 0.0 | 0.1 |
| Isaiah Davis | NYJ | CIN | Away | 4.5 | 36.0 | 0.0 | 2.3 | 0.0 | 0.0 |
| Kareem Hunt | KC | WAS | Home | 9.8 | 34.3 | 1.0 | 3.6 | 0.4 | 0.0 |
| Brian Robinson | SF | HOU | Away | 9.5 | 34.3 | 0.1 | 1.5 | 0.1 | 0.1 |
| Chris Rodriguez Jr. | WAS | KC | Away | 7.4 | 34.2 | 0.8 | 2.0 | 0.0 | 0.1 |
| RJ Harvey | DEN | DAL | Home | 7.7 | 34.2 | 0.0 | 1.3 | 0.0 | 0.0 |
| Will Shipley | PHI | NYG | Home | 7.6 | 34.0 | 0.1 | 1.5 | 0.0 | 0.0 |
| Kyle Monangai | CHI | BAL | Away | 7.4 | 32.3 | 0.5 | 1.9 | 0.0 | 0.0 |
| Spencer Rattler | NO | TB | Home | 5.7 | 32.1 | 0.1 | 2.7 | 0.0 | 0.0 |
| Bo Nix | DEN | DAL | Home | 6.5 | 31.8 | 0.8 | 2.8 | 0.3 | 0.0 |
| Rhamondre Stevenson | NE | CLE | Home | 11.2 | 31.1 | 0.9 | 1.3 | 0.9 | 1.1 |
| Carson Wentz | MIN | LAC | Away | 4.7 | 29.7 | 0.1 | 3.3 | 1.3 | 0.1 |
| Trevor Etienne | CAR | BUF | Home | 5.3 | 29.6 | 0.1 | 2.5 | 0.1 | 0.2 |
| Brashard Smith | KC | WAS | Home | 11.1 | 29.4 | 0.0 | 0.7 | 0.0 | 0.0 |
| Sean Tucker | TB | NO | Away | 7.0 | 29.1 | 0.7 | 2.1 | 0.2 | 0.1 |
| Malik Washington | MIA | ATL | Away | 3.8 | 28.7 | 0.0 | 2.1 | 0.1 | 0.0 |
| Hassan Haskins | LAC | MIN | Home | 10.4 | 28.4 | 0.8 | 3.5 | 0.1 | 0.2 |
| Woody Marks | HOU | SF | Home | 9.5 | 28.2 | 0.4 | 1.5 | 0.1 | 0.0 |
| Samaje Perine | CIN | NYJ | Home | 6.6 | 28.2 | 0.0 | 2.8 | 0.7 | 0.8 |
| C.J. Stroud | HOU | SF | Home | 5.8 | 26.7 | 0.0 | 2.3 | 0.0 | 0.0 |
| Drake Maye | NE | CLE | Home | 7.2 | 26.1 | 0.6 | 2.1 | 0.9 | 0.6 |
| Kenneth Gainwell | PIT | GB | Home | 8.9 | 24.7 | 0.7 | 1.5 | 0.3 | 0.0 |
| Devin Singletary | NYG | PHI | Away | 6.7 | 24.6 | 0.0 | 2.2 | 0.1 | 0.1 |
| Dak Prescott | DAL | DEN | Away | 6.9 | 24.4 | 0.0 | 2.3 | 1.2 | 0.1 |
| Zavier Scott | MIN | LAC | Away | 6.7 | 22.6 | 0.1 | 2.0 | 1.4 | 1.1 |
| Jordan Love | GB | PIT | Away | 5.3 | 22.4 | 0.0 | 2.4 | 0.8 | 0.2 |
| Caleb Williams | CHI | BAL | Away | 5.7 | 22.2 | 0.6 | 2.0 | 1.1 | 0.0 |
| Daniel Jones | IND | TEN | Home | 6.6 | 21.9 | 1.8 | 3.1 | 0.1 | 0.1 |
| TreVeyon Henderson | NE | CLE | Home | 7.8 | 21.1 | 0.4 | 1.1 | 0.2 | 0.2 |
| Jerome Ford | CLE | NE | Away | 6.7 | 19.5 | 0.0 | 1.1 | 0.0 | 0.0 |
| Tahj Brooks | CIN | NYJ | Home | 6.2 | 18.9 | 0.0 | 0.1 | 0.1 | 0.0 |
| Ollie Gordon II | MIA | ATL | Away | 6.9 | 18.7 | 0.6 | 2.8 | 0.1 | 0.0 |
| Deebo Samuel Sr. | WAS | KC | Away | 3.8 | 18.0 | 0.0 | 1.3 | 0.0 | 0.1 |
| Kaleb Johnson | PIT | GB | Home | 7.3 | 17.6 | 0.0 | 0.6 | 0.0 | 0.0 |
| Jaydon Blue | DAL | DEN | Away | 6.4 | 17.4 | 0.0 | 1.2 | 0.0 | 0.1 |
| Michael Penix Jr. | ATL | MIA | Home | 5.6 | 16.9 | 1.0 | 3.1 | 0.9 | 0.0 |
| Ty Johnson | BUF | CAR | Away | 3.4 | 16.3 | 0.0 | 1.4 | 0.0 | 0.1 |
| Mac Jones | SF | HOU | Away | 7.2 | 16.2 | 0.1 | 3.0 | 0.6 | 0.1 |
| Keaton Mitchell | BAL | CHI | Home | 7.1 | 15.8 | 0.0 | 1.8 | 0.2 | 0.5 |
| Terrell Jennings | NE | CLE | Home | 7.3 | 15.5 | 0.0 | 0.1 | 0.2 | 0.2 |
| Dylan Sampson | CLE | NE | Away | 6.3 | 12.8 | 0.0 | 1.1 | 0.0 | 0.0 |
| Dillon Gabriel | CLE | NE | Away | 4.8 | 11.8 | 0.0 | 0.3 | 0.0 | 0.0 |
| Aaron Rodgers | PIT | GB | Home | 6.3 | 10.9 | 0.0 | 0.9 | 0.8 | 0.0 |
| Davis Mills | HOU | SF | Home | 4.9 | 10.5 | 0.0 | 1.0 | 0.0 | 0.0 |
| Matthew Golden | GB | PIT | Away | 3.9 | 9.8 | 0.0 | 0.8 | 0.2 | 0.2 |
| Tua Tagovailoa | MIA | ATL | Away | 4.0 | 7.4 | 0.0 | 2.8 | 1.7 | 0.0 |
| AJ Dillon | PHI | NYG | Home | 2.2 | 7.0 | 0.1 | 0.4 | 0.1 | 0.0 |
| DJ Moore | CHI | BAL | Away | 3.0 | 6.7 | 0.1 | 0.5 | 0.0 | 0.0 |
| Joshua Dobbs | NE | CLE | Home | 6.5 | 5.4 | 0.9 | 0.2 | 1.2 | 1.3 |
| Cam Ward | TEN | IND | Away | 4.2 | 4.3 | 0.0 | 1.2 | 0.0 | 0.1 |
| Cooper Rush | BAL | CHI | Home | 4.4 | 2.3 | 0.0 | 0.9 | 0.1 | 0.4 |
| Raheim Sanders | CLE | NE | Away | 3.6 | 2.1 | 1.0 | 1.9 | 0.0 | 0.0 |
| Joe Flacco | CIN | NE | Away | 4.7 | 1.6 | 0.0 | 1.0 | 0.0 | 0.0 |
| Taysom Hill | NO | TB | Home | 7.4 | 0.0 | 0.1 | 0.8 | 0.0 | 0.0 |