| Player | Team | Opponent | Venue | Attempts | Yards | TDs | 1st Downs | Fumbles | Fumbles Lost |
|---|---|---|---|---|---|---|---|---|---|
| De'Von Achane | MIA | PIT | Away | 18.5 | 116.7 | 1.0 | 5.3 | 0.7 | 0.2 |
| Derrick Henry | BAL | CIN | Away | 18.4 | 105.4 | 1.3 | 4.9 | 0.6 | 0.6 |
| Bijan Robinson | ATL | TB | Away | 16.1 | 94.9 | 0.9 | 4.0 | 0.8 | 0.7 |
| Javonte Williams | DAL | MIN | Home | 20.8 | 91.9 | 1.2 | 5.8 | 0.5 | 0.5 |
| Rico Dowdle | CAR | NO | Away | 17.7 | 88.1 | 0.6 | 4.4 | 0.2 | 0.1 |
| Quinshon Judkins | CLE | CHI | Away | 19.0 | 83.8 | 1.0 | 5.1 | 0.3 | 0.2 |
| James Cook | BUF | NE | Away | 18.3 | 83.6 | 0.7 | 4.8 | 1.0 | 0.9 |
| Travis Etienne | JAX | NYJ | Home | 20.1 | 83.4 | 1.3 | 4.4 | 0.1 | 0.0 |
| Jahmyr Gibbs | DET | LA | Away | 15.3 | 79.4 | 1.2 | 4.2 | 0.0 | 0.1 |
| Christian McCaffrey | SF | TEN | Home | 19.9 | 75.3 | 1.4 | 5.8 | 0.3 | 0.1 |
| Josh Jacobs | GB | DEN | Away | 19.4 | 74.9 | 1.7 | 4.5 | 0.5 | 0.4 |
| Jonathan Taylor | IND | SEA | Away | 16.9 | 74.6 | 2.0 | 4.8 | 0.1 | 0.4 |
| Kyren Williams | LA | DET | Home | 17.4 | 72.3 | 1.0 | 5.3 | 0.6 | 0.7 |
| Bucky Irving | TB | ATL | Home | 19.6 | 70.7 | 0.3 | 3.5 | 0.6 | 0.7 |
| Kimani Vidal | LAC | KC | Away | 16.7 | 70.0 | 0.6 | 4.0 | 0.3 | 0.1 |
| D'Andre Swift | CHI | CLE | Home | 17.1 | 69.2 | 0.7 | 4.4 | 0.8 | 0.8 |
| Emari Demercado | ARI | HOU | Away | 8.1 | 66.7 | 0.0 | 2.3 | 0.6 | 0.9 |
| Omarion Hampton | LAC | KC | Away | 15.2 | 66.1 | 0.6 | 4.1 | 0.0 | 0.1 |
| TreVeyon Henderson | NE | BUF | Home | 13.4 | 66.0 | 1.2 | 4.1 | 0.4 | 0.5 |
| Jaylen Warren | PIT | MIA | Home | 15.8 | 64.4 | 0.7 | 4.3 | 0.1 | 0.1 |
| Saquon Barkley | PHI | LV | Home | 18.3 | 63.9 | 1.0 | 3.5 | 0.1 | 0.1 |
| Ashton Jeanty | LV | PHI | Away | 17.1 | 62.8 | 0.7 | 4.1 | 0.4 | 0.4 |
| Jaylen Wright | MIA | PIT | Away | 13.4 | 60.5 | 0.4 | 4.2 | 0.4 | 0.2 |
| Tony Pollard | TEN | SF | Away | 15.2 | 60.3 | 0.4 | 3.6 | 0.5 | 0.7 |
| Kenneth Walker III | SEA | IND | Home | 15.6 | 58.9 | 0.7 | 4.1 | 0.0 | 0.1 |
| Jacory Croskey-Merritt | WAS | NYG | Away | 11.5 | 55.9 | 0.7 | 2.9 | 0.4 | 0.6 |
| Breece Hall | NYJ | JAX | Away | 14.9 | 54.7 | 0.3 | 3.7 | 0.5 | 0.7 |
| Chris Rodriguez Jr. | WAS | NYG | Away | 10.8 | 54.5 | 1.0 | 3.6 | 0.0 | 0.0 |
| Kareem Hunt | KC | LAC | Home | 14.2 | 53.7 | 1.5 | 5.1 | 0.6 | 0.4 |
| Jordan Mason | MIN | DAL | Away | 12.1 | 53.2 | 1.1 | 4.3 | 0.4 | 0.4 |
| Jayden Daniels | WAS | NYG | Away | 10.0 | 52.6 | 0.7 | 2.9 | 0.4 | 0.6 |
| Marcus Mariota | WAS | NYG | Away | 8.2 | 51.6 | 0.5 | 2.9 | 1.0 | 0.8 |
| Sean Tucker | TB | ATL | Home | 12.5 | 51.4 | 1.0 | 3.6 | 0.6 | 0.0 |
| Kyle Monangai | CHI | CLE | Home | 14.0 | 51.4 | 0.7 | 3.1 | 0.3 | 0.2 |
| Chase Brown | CIN | BAL | Home | 14.6 | 50.9 | 0.6 | 3.5 | 0.4 | 0.2 |
| Woody Marks | HOU | ARI | Home | 15.4 | 50.2 | 0.5 | 3.5 | 0.4 | 0.1 |
| Rachaad White | TB | ATL | Home | 13.2 | 49.4 | 0.7 | 4.3 | 0.1 | 0.0 |
| Alvin Kamara | NO | CAR | Home | 13.4 | 48.9 | 0.3 | 2.4 | 0.3 | 0.4 |
| Jaxson Dart | NYG | WAS | Home | 9.2 | 48.2 | 1.4 | 4.9 | 0.9 | 0.5 |
| Isiah Pacheco | KC | LAC | Home | 11.7 | 48.2 | 0.4 | 3.6 | 0.0 | 0.1 |
| Keaton Mitchell | BAL | CIN | Away | 5.4 | 47.2 | 0.0 | 1.6 | 0.5 | 0.1 |
| Patrick Mahomes | KC | LAC | Home | 7.0 | 46.9 | 1.1 | 3.7 | 0.0 | 0.0 |
| Chuba Hubbard | CAR | NO | Away | 12.7 | 46.8 | 0.1 | 3.2 | 0.2 | 0.1 |
| Aaron Jones | MIN | DAL | Away | 12.0 | 46.7 | 0.2 | 4.2 | 0.0 | 0.0 |
| Lamar Jackson | BAL | CIN | Away | 7.7 | 46.1 | 0.4 | 3.0 | 0.0 | 0.1 |
| Nick Chubb | HOU | ARI | Home | 12.2 | 46.0 | 0.7 | 2.6 | 0.1 | 0.1 |
| Jeremy McNichols | WAS | NYG | Away | 5.7 | 45.8 | 0.5 | 2.7 | 0.0 | 0.1 |
| Blake Corum | LA | DET | Home | 11.1 | 45.1 | 0.7 | 3.3 | 0.1 | 0.1 |
| Tyrone Tracy Jr. | NYG | WAS | Home | 12.9 | 45.1 | 0.2 | 3.1 | 0.1 | 0.0 |
| Jaret Patterson | LAC | KC | Away | 12.4 | 44.4 | 0.6 | 2.4 | 0.0 | 0.1 |
| Rhamondre Stevenson | NE | BUF | Home | 12.8 | 43.8 | 1.0 | 2.1 | 0.7 | 0.9 |
| David Montgomery | DET | LA | Away | 11.4 | 40.7 | 0.5 | 2.9 | 0.4 | 0.4 |
| Justin Herbert | LAC | KC | Away | 7.8 | 40.3 | 0.1 | 3.6 | 0.6 | 0.5 |
| Zach Charbonnet | SEA | IND | Home | 13.5 | 39.6 | 1.3 | 3.4 | 0.0 | 0.1 |
| Emanuel Wilson | GB | DEN | Away | 11.1 | 38.1 | 0.5 | 2.9 | 0.0 | 0.1 |
| Devin Neal | NO | CAR | Home | 11.0 | 37.8 | 0.5 | 2.0 | 0.0 | 0.1 |
| RJ Harvey | DEN | GB | Home | 11.2 | 37.7 | 0.9 | 2.4 | 0.0 | 0.0 |
| Tank Bigsby | PHI | LV | Home | 6.3 | 36.7 | 0.0 | 2.6 | 0.1 | 0.1 |
| Kenneth Gainwell | PIT | MIA | Home | 8.2 | 36.6 | 0.7 | 2.8 | 0.4 | 0.2 |
| Bam Knight | ARI | HOU | Away | 11.3 | 36.1 | 0.9 | 3.2 | 0.2 | 0.5 |
| Baker Mayfield | TB | ATL | Home | 5.5 | 35.9 | 0.2 | 3.4 | 0.5 | 0.0 |
| Josh Allen | BUF | NE | Away | 7.9 | 35.4 | 1.1 | 3.7 | 0.9 | 0.7 |
| Tyler Allgeier | ATL | TB | Away | 10.5 | 35.1 | 1.6 | 2.8 | 0.1 | 0.1 |
| Brian Robinson | SF | TEN | Home | 8.7 | 35.0 | 0.6 | 2.3 | 0.0 | 0.0 |
| Raheem Mostert | LV | PHI | Away | 6.5 | 34.6 | 0.1 | 2.4 | 0.2 | 0.1 |
| Devin Singletary | NYG | WAS | Home | 10.1 | 34.0 | 0.7 | 2.4 | 0.1 | 0.0 |
| Drake Maye | NE | BUF | Home | 7.9 | 33.8 | 0.6 | 3.3 | 0.3 | 0.2 |
| Shedeur Sanders | CLE | CHI | Away | 3.2 | 33.5 | 0.9 | 2.2 | 0.3 | 0.2 |
| Samaje Perine | CIN | BAL | Home | 8.4 | 33.3 | 0.3 | 3.4 | 1.0 | 1.1 |
| Ray Davis | BUF | NE | Away | 10.5 | 32.7 | 0.0 | 2.2 | 0.0 | 0.1 |
| Bhayshul Tuten | JAX | NYJ | Home | 8.7 | 31.8 | 1.0 | 2.6 | 0.1 | 0.0 |
| Trevor Lawrence | JAX | NYJ | Home | 7.0 | 29.9 | 1.2 | 3.7 | 0.4 | 0.4 |
| Ollie Gordon II | MIA | PIT | Away | 7.8 | 29.9 | 0.7 | 3.4 | 0.4 | 0.2 |
| Malik Davis | DAL | MIN | Home | 3.7 | 29.0 | 0.5 | 1.2 | 0.2 | 0.1 |
| J.J. McCarthy | MIN | DAL | Away | 7.7 | 28.8 | 0.7 | 2.7 | 1.1 | 0.1 |
| C.J. Stroud | HOU | ARI | Home | 5.9 | 28.2 | 0.1 | 3.5 | 0.1 | 0.1 |
| Jalen Hurts | PHI | LV | Home | 8.9 | 26.8 | 1.4 | 3.8 | 1.0 | 0.8 |
| Michael Carter | ARI | HOU | Away | 9.0 | 26.7 | 0.3 | 1.8 | 0.0 | 0.0 |
| Trevor Etienne | CAR | NO | Away | 5.2 | 26.2 | 0.0 | 2.1 | 0.2 | 0.1 |
| Tyrod Taylor | NYJ | JAX | Away | 6.3 | 25.6 | 0.2 | 2.3 | 0.0 | 0.1 |
| Caleb Williams | CHI | CLE | Home | 5.8 | 24.4 | 0.4 | 2.1 | 1.2 | 0.2 |
| Malik Washington | MIA | PIT | Away | 3.2 | 24.4 | 0.0 | 1.1 | 1.7 | 1.4 |
| Tyjae Spears | TEN | SF | Away | 6.9 | 24.0 | 0.1 | 1.5 | 0.0 | 0.1 |
| Rasheen Ali | BAL | CIN | Away | 4.7 | 23.8 | 0.0 | 1.3 | 0.0 | 0.1 |
| Jaleel McLaughlin | DEN | GB | Home | 6.7 | 23.7 | 0.6 | 1.7 | 0.0 | 0.0 |
| Jacoby Brissett | ARI | HOU | Away | 5.0 | 23.1 | 0.3 | 2.4 | 0.3 | 0.0 |
| Bo Nix | DEN | GB | Home | 6.0 | 22.8 | 0.7 | 1.9 | 0.3 | 0.0 |
| Tyler Shough | NO | CAR | Home | 6.4 | 22.3 | 1.0 | 1.9 | 0.6 | 0.8 |
| Dylan Sampson | CLE | CHI | Away | 6.2 | 22.3 | 0.0 | 1.6 | 0.3 | 0.2 |
| Isaiah Davis | NYJ | JAX | Away | 4.9 | 22.2 | 0.0 | 0.5 | 0.0 | 0.1 |
| Brashard Smith | KC | LAC | Home | 7.9 | 20.6 | 0.1 | 1.1 | 0.8 | 0.0 |
| Bryce Young | CAR | NO | Away | 4.4 | 20.1 | 0.0 | 1.1 | 0.9 | 0.8 |
| Kaleb Johnson | PIT | MIA | Home | 7.0 | 20.0 | 0.0 | 1.2 | 0.1 | 0.1 |
| Jordan Love | GB | DEN | Away | 4.9 | 19.8 | 0.0 | 1.8 | 0.6 | 0.1 |
| Jaydon Blue | DAL | MIN | Home | 6.7 | 19.0 | 0.0 | 1.3 | 1.0 | 0.2 |
| Brock Purdy | SF | TEN | Home | 6.7 | 18.5 | 0.1 | 2.9 | 0.0 | 0.0 |
| Zavier Scott | MIN | DAL | Away | 5.7 | 18.5 | 0.1 | 1.6 | 0.9 | 0.8 |
| Cam Ward | TEN | SF | Away | 5.0 | 18.2 | 0.3 | 2.6 | 0.0 | 0.1 |
| Jake Browning | CIN | BAL | Home | 4.2 | 18.2 | 0.0 | 1.9 | 0.1 | 0.2 |
| Dak Prescott | DAL | MIN | Home | 5.6 | 17.6 | 0.2 | 2.3 | 0.9 | 0.1 |
| Tyler Badie | DEN | GB | Home | 4.8 | 17.2 | 0.0 | 1.1 | 0.0 | 0.0 |
| AJ Dillon | PHI | LV | Home | 2.8 | 15.6 | 0.1 | 0.5 | 0.2 | 0.2 |
| Hassan Haskins | LAC | KC | Away | 6.8 | 15.5 | 0.0 | 1.4 | 0.0 | 0.1 |
| Evan Hull | NO | CAR | Home | 5.9 | 15.2 | 0.0 | 2.5 | 0.0 | 0.1 |
| Geno Smith | LV | PHI | Away | 4.8 | 15.1 | 0.0 | 2.5 | 0.2 | 0.1 |
| Ty Johnson | BUF | NE | Away | 3.7 | 14.9 | 0.0 | 0.5 | 0.0 | 0.1 |
| Parker Washington | JAX | NYJ | Home | 3.3 | 13.7 | 0.0 | 2.9 | 0.1 | 0.0 |
| Jameis Winston | NYG | WAS | Home | 4.1 | 12.3 | 1.0 | 1.9 | 0.1 | 0.0 |
| Jared Goff | DET | LA | Away | 4.2 | 11.8 | 0.0 | 2.1 | 1.1 | 0.1 |
| Audric Estimé | NO | CAR | Home | 3.5 | 10.2 | 0.0 | 1.0 | 0.0 | 0.1 |
| Matthew Golden | GB | DEN | Away | 3.4 | 10.0 | 0.0 | 0.2 | 0.0 | 0.1 |
| Clyde Edwards-Helaire | KC | LAC | Home | 6.1 | 9.9 | 0.1 | 1.4 | 0.0 | 0.1 |
| Joe Burrow | CIN | BAL | Home | 3.3 | 9.4 | 0.0 | 2.3 | 0.1 | 0.2 |
| D'Ernest Johnson | NE | BUF | Home | 3.6 | 8.7 | 0.1 | 0.2 | 0.0 | 0.2 |
| Tua Tagovailoa | MIA | PIT | Away | 3.6 | 6.6 | 0.0 | 1.8 | 1.7 | 0.2 |
| Sam Darnold | SEA | IND | Home | 3.7 | 5.5 | 0.0 | 1.3 | 0.8 | 1.0 |
| Myles Gaskin | SEA | IND | Home | 3.3 | 5.4 | 0.0 | 0.0 | 0.0 | 0.1 |
| Aaron Rodgers | PIT | MIA | Home | 3.4 | 2.8 | 0.0 | 0.0 | 1.1 | 0.2 |
| Mark Andrews | BAL | CIN | Away | 3.4 | 2.3 | 0.0 | 1.3 | 0.0 | 0.1 |
| Matthew Stafford | LA | DET | Home | 4.5 | 0.4 | 0.0 | 0.4 | 1.1 | 0.1 |
| Jimmy Garoppolo | LA | DET | Home | 3.2 | 0.0 | 0.0 | 0.0 | 0.1 | 0.1 |