| Player | Team | Opponent | Venue | Completions | Attempts | Yards | TDs | INTs | Sacks | Fumbles |
|---|---|---|---|---|---|---|---|---|---|---|
| Matthew Stafford | LA | ARI | Home | 26.3 | 37.9 | 302.4 | 3.1 | 0.5 | 1.4 | 0.4 |
| Drake Maye | NE | MIA | Home | 25.0 | 31.8 | 285.3 | 3.0 | 0.3 | 4.4 | 1.0 |
| Dak Prescott | DAL | NYG | Away | 25.6 | 36.8 | 279.4 | 2.4 | 0.8 | 2.6 | 0.6 |
| Sam Darnold | SEA | SF | Away | 23.2 | 33.4 | 278.2 | 2.7 | 0.8 | 1.4 | 1.0 |
| Jacoby Brissett | ARI | LA | Away | 27.0 | 40.7 | 274.0 | 2.3 | 1.5 | 4.4 | 0.7 |
| C.J. Stroud | HOU | IND | Home | 23.7 | 35.8 | 272.8 | 1.8 | 1.0 | 2.5 | 0.0 |
| Brock Purdy | SF | SEA | Home | 26.3 | 37.5 | 269.8 | 2.5 | 2.4 | 1.8 | 0.7 |
| Caleb Williams | CHI | DET | Home | 21.0 | 36.2 | 268.0 | 2.7 | 0.4 | 2.8 | 0.4 |
| Trevor Lawrence | JAX | TEN | Home | 21.2 | 32.9 | 265.6 | 2.5 | 0.6 | 3.6 | 0.4 |
| Jared Goff | DET | CHI | Away | 22.0 | 32.4 | 262.4 | 3.0 | 1.9 | 2.6 | 0.6 |
| Jalen Hurts | PHI | WAS | Home | 20.5 | 30.7 | 260.6 | 2.9 | 0.0 | 2.9 | 0.2 |
| Lamar Jackson | BAL | PIT | Away | 19.2 | 30.6 | 252.1 | 2.5 | 1.5 | 4.5 | 1.1 |
| Tyler Shough | NO | ATL | Away | 22.6 | 33.9 | 248.9 | 1.7 | 1.6 | 5.3 | 0.9 |
| Bo Nix | DEN | LAC | Home | 22.7 | 36.9 | 243.9 | 1.5 | 1.6 | 1.8 | 0.3 |
| Jaxson Dart | NYG | DAL | Home | 20.2 | 30.3 | 243.7 | 2.3 | 0.2 | 3.3 | 0.1 |
| Josh Allen | BUF | NYJ | Home | 20.2 | 29.4 | 243.5 | 2.7 | 0.0 | 2.4 | 0.0 |
| Aaron Rodgers | PIT | BAL | Home | 22.9 | 34.1 | 237.9 | 1.8 | 0.3 | 1.5 | 0.3 |
| Justin Herbert | LAC | DEN | Away | 20.4 | 33.6 | 235.0 | 1.4 | 1.0 | 6.0 | 0.4 |
| Joe Burrow | CIN | CLE | Home | 18.9 | 29.6 | 232.1 | 2.3 | 0.8 | 4.2 | 0.1 |
| Jordan Love | GB | MIN | Away | 18.4 | 29.4 | 227.8 | 1.3 | 0.5 | 2.3 | 0.4 |
| Baker Mayfield | TB | CAR | Home | 19.3 | 30.3 | 227.2 | 1.5 | 0.8 | 2.0 | 0.9 |
| Bryce Young | CAR | TB | Away | 20.7 | 32.4 | 219.1 | 2.3 | 1.3 | 2.4 | 0.6 |
| Shedeur Sanders | CLE | CIN | Away | 16.9 | 28.4 | 219.0 | 1.9 | 2.2 | 2.8 | 0.5 |
| Geno Smith | LV | KC | Home | 21.3 | 30.4 | 213.4 | 1.1 | 1.5 | 4.0 | 0.2 |
| Malik Willis | GB | MIN | Away | 14.1 | 19.0 | 209.2 | 0.8 | 0.2 | 2.5 | 0.0 |
| Cam Ward | TEN | JAX | Away | 21.0 | 35.5 | 204.2 | 1.2 | 1.7 | 3.6 | 0.9 |
| Tyler Huntley | BAL | PIT | Away | 17.2 | 24.0 | 193.8 | 1.1 | 0.9 | 3.3 | 0.3 |
| Philip Rivers | IND | HOU | Away | 19.3 | 33.2 | 190.9 | 1.4 | 2.3 | 2.9 | 1.1 |
| Kirk Cousins | ATL | NO | Home | 17.4 | 27.5 | 185.0 | 1.3 | 0.3 | 1.6 | 0.7 |
| J.J. McCarthy | MIN | GB | Home | 16.9 | 28.1 | 180.1 | 1.7 | 1.4 | 3.9 | 0.4 |
| Brady Cook | NYJ | BUF | Away | 18.0 | 32.0 | 170.9 | 0.2 | 2.1 | 5.1 | 1.1 |
| Quinn Ewers | MIA | NE | Away | 14.7 | 22.3 | 168.1 | 0.9 | 0.9 | 1.4 | 0.6 |
| Josh Johnson | WAS | PHI | Away | 12.9 | 20.4 | 135.3 | 0.0 | 1.0 | 1.4 | 0.3 |
| Max Brosmer | MIN | GB | Home | 15.1 | 22.8 | 111.8 | 0.1 | 1.5 | 4.9 | 0.7 |
| Chris Oladokun | KC | LV | Away | 15.1 | 21.9 | 96.8 | 0.8 | 0.3 | 2.9 | 1.1 |