| Player | Team | Opponent | Venue | Completions | Attempts | Yards | TDs | INTs | Sacks | Fumbles |
|---|---|---|---|---|---|---|---|---|---|---|
| Patrick Mahomes | KC | WAS | Home | 23.5 | 36.1 | 280.6 | 2.7 | 0.1 | 1.9 | 0.6 |
| Justin Herbert | LAC | MIN | Home | 26.1 | 36.3 | 280.5 | 2.2 | 1.1 | 3.5 | 0.0 |
| Dak Prescott | DAL | DEN | Away | 25.9 | 39.2 | 276.0 | 2.2 | 0.3 | 1.4 | 0.0 |
| Jordan Love | GB | PIT | Away | 25.3 | 35.8 | 268.9 | 2.0 | 0.6 | 2.8 | 0.5 |
| Mac Jones | SF | HOU | Away | 22.4 | 32.9 | 268.2 | 1.0 | 1.7 | 2.9 | 0.7 |
| Baker Mayfield | TB | NO | Away | 23.1 | 35.0 | 266.6 | 3.0 | 0.5 | 2.5 | 1.1 |
| Jalen Hurts | PHI | NYG | Home | 23.9 | 35.6 | 260.0 | 2.0 | 0.1 | 3.5 | 0.6 |
| Daniel Jones | IND | TEN | Home | 21.4 | 28.6 | 253.3 | 1.5 | 0.4 | 0.9 | 0.0 |
| Bo Nix | DEN | DAL | Home | 23.1 | 33.7 | 242.8 | 2.8 | 0.4 | 1.4 | 0.4 |
| Aaron Rodgers | PIT | GB | Home | 26.6 | 37.0 | 240.8 | 3.2 | 1.5 | 3.2 | 0.2 |
| Spencer Rattler | NO | TB | Home | 24.4 | 36.8 | 240.2 | 1.6 | 1.1 | 3.8 | 1.0 |
| Michael Penix Jr. | ATL | MIA | Home | 21.0 | 34.0 | 237.9 | 1.6 | 0.7 | 1.7 | 0.8 |
| Carson Wentz | MIN | LAC | Away | 21.2 | 33.7 | 231.1 | 0.8 | 1.9 | 3.6 | 0.2 |
| Joe Flacco | CIN | NE | Away | 23.8 | 38.7 | 224.5 | 1.3 | 1.4 | 2.1 | 0.5 |
| Drake Maye | NE | CLE | Home | 20.0 | 27.6 | 224.0 | 2.1 | 0.2 | 4.1 | 0.2 |
| Josh Allen | BUF | CAR | Away | 19.7 | 30.6 | 223.4 | 2.4 | 1.0 | 2.5 | 0.0 |
| Cam Ward | TEN | IND | Away | 21.1 | 36.2 | 222.5 | 0.8 | 1.8 | 3.4 | 1.0 |
| C.J. Stroud | HOU | SF | Home | 21.2 | 32.4 | 220.4 | 2.3 | 0.2 | 2.0 | 0.1 |
| Lamar Jackson | BAL | CHI | Home | 16.0 | 22.5 | 215.9 | 3.4 | 0.3 | 2.9 | 0.9 |
| Jaxson Dart | NYG | PHI | Away | 18.9 | 33.5 | 208.6 | 1.6 | 1.8 | 2.8 | 0.3 |
| Justin Fields | NYJ | CIN | Away | 17.9 | 27.4 | 205.7 | 1.5 | 0.7 | 3.3 | 0.8 |
| Caleb Williams | CHI | BAL | Away | 19.1 | 32.2 | 204.7 | 1.4 | 0.6 | 2.0 | 0.5 |
| Tua Tagovailoa | MIA | ATL | Away | 18.7 | 29.7 | 194.6 | 1.9 | 2.1 | 2.9 | 0.3 |
| Jayden Daniels | WAS | KC | Away | 16.9 | 27.3 | 192.0 | 1.4 | 0.3 | 3.2 | 0.7 |
| Dillon Gabriel | CLE | NE | Away | 20.3 | 32.4 | 185.8 | 0.5 | 0.4 | 3.2 | 0.1 |
| Marcus Mariota | WAS | KC | Away | 13.0 | 19.3 | 161.9 | 1.1 | 0.5 | 2.1 | 0.2 |
| Cooper Rush | BAL | CHI | Home | 13.2 | 18.7 | 148.1 | 0.4 | 3.1 | 0.3 | 0.4 |
| Andy Dalton | CAR | BUF | Home | 6.2 | 8.8 | 81.9 | 0.2 | 0.0 | 0.8 | 0.3 |
| Quinn Ewers | MIA | ATL | Away | 5.5 | 12.0 | 50.0 | 0.3 | 0.8 | 2.7 | 1.2 |
| Kirk Cousins | ATL | MIA | Home | 7.7 | 13.6 | 7.3 | 0.1 | 0.0 | 0.0 | 0.1 |