| Player | Team | Opponent | Venue | Completions | Attempts | Yards | TDs | INTs | Sacks | Fumbles |
|---|---|---|---|---|---|---|---|---|---|---|
| Matthew Stafford | LA | DET | Home | 23.9 | 35.7 | 284.9 | 3.6 | 0.3 | 2.3 | 0.7 |
| Sam Darnold | SEA | IND | Home | 21.4 | 33.1 | 279.4 | 2.0 | 1.7 | 2.0 | 0.8 |
| Jacoby Brissett | ARI | HOU | Away | 26.4 | 42.8 | 272.5 | 1.8 | 1.8 | 5.0 | 1.1 |
| Dak Prescott | DAL | MIN | Home | 24.3 | 35.3 | 264.1 | 2.2 | 0.4 | 2.5 | 0.1 |
| Brock Purdy | SF | TEN | Home | 23.5 | 33.2 | 261.5 | 2.7 | 1.7 | 1.2 | 0.2 |
| Drake Maye | NE | BUF | Home | 19.7 | 28.9 | 260.0 | 1.9 | 0.4 | 3.7 | 1.0 |
| Patrick Mahomes | KC | LAC | Home | 22.7 | 36.7 | 256.1 | 1.6 | 2.1 | 3.6 | 0.6 |
| Tua Tagovailoa | MIA | PIT | Away | 21.5 | 35.6 | 253.4 | 2.1 | 1.9 | 3.2 | 0.5 |
| Jared Goff | DET | LA | Away | 22.7 | 33.3 | 252.8 | 2.2 | 1.1 | 3.0 | 0.5 |
| Lamar Jackson | BAL | CIN | Away | 17.8 | 29.8 | 251.0 | 2.6 | 1.1 | 2.8 | 0.9 |
| Jaxson Dart | NYG | WAS | Home | 20.0 | 30.7 | 250.7 | 2.6 | 0.1 | 3.9 | 0.0 |
| C.J. Stroud | HOU | ARI | Home | 22.5 | 34.7 | 250.1 | 1.7 | 0.8 | 2.6 | 0.2 |
| Josh Allen | BUF | NE | Away | 21.1 | 30.3 | 240.4 | 2.3 | 1.2 | 2.9 | 0.0 |
| Bo Nix | DEN | GB | Home | 25.9 | 38.8 | 235.4 | 1.9 | 0.5 | 2.0 | 0.3 |
| Jordan Love | GB | DEN | Away | 19.0 | 31.3 | 234.2 | 1.4 | 0.3 | 2.5 | 0.4 |
| Jalen Hurts | PHI | LV | Home | 21.6 | 32.4 | 233.0 | 2.0 | 0.4 | 2.6 | 0.4 |
| Caleb Williams | CHI | CLE | Home | 18.8 | 30.9 | 230.0 | 1.9 | 0.5 | 2.8 | 0.2 |
| Justin Herbert | LAC | KC | Away | 21.1 | 32.3 | 229.3 | 1.6 | 1.2 | 3.6 | 0.4 |
| Cam Ward | TEN | SF | Away | 23.6 | 37.9 | 228.7 | 1.4 | 0.5 | 2.8 | 1.0 |
| Trevor Lawrence | JAX | NYJ | Home | 19.4 | 31.8 | 226.9 | 1.9 | 0.1 | 2.4 | 0.2 |
| Jayden Daniels | WAS | NYG | Away | 18.6 | 32.6 | 226.0 | 2.0 | 0.4 | 3.5 | 0.8 |
| Baker Mayfield | TB | ATL | Home | 21.0 | 33.4 | 225.3 | 2.2 | 0.7 | 3.4 | 1.3 |
| Aaron Rodgers | PIT | MIA | Home | 21.0 | 30.3 | 220.0 | 2.3 | 0.4 | 2.3 | 0.5 |
| Tyler Shough | NO | CAR | Home | 19.1 | 28.0 | 210.7 | 0.5 | 1.4 | 2.2 | 0.1 |
| Shedeur Sanders | CLE | CHI | Away | 14.4 | 25.6 | 209.1 | 2.3 | 2.1 | 2.2 | 0.8 |
| J.J. McCarthy | MIN | DAL | Away | 16.6 | 29.2 | 206.9 | 2.5 | 1.7 | 3.9 | 0.5 |
| Joe Burrow | CIN | BAL | Home | 19.3 | 32.8 | 202.3 | 2.2 | 0.5 | 1.6 | 0.0 |
| Bryce Young | CAR | NO | Away | 18.9 | 30.8 | 198.5 | 2.2 | 1.2 | 2.4 | 0.8 |
| Brady Cook | NYJ | JAX | Away | 15.2 | 33.1 | 178.3 | 0.2 | 1.9 | 4.6 | 0.9 |
| Tyrod Taylor | NYJ | JAX | Away | 16.7 | 29.4 | 175.3 | 1.4 | 1.8 | 2.8 | 0.5 |
| Kirk Cousins | ATL | TB | Away | 15.5 | 25.9 | 170.4 | 0.9 | 1.3 | 1.8 | 0.5 |
| Kenny Pickett | LV | PHI | Away | 10.1 | 19.3 | 128.4 | 1.0 | 0.7 | 1.7 | 0.2 |